Effectiveness Test of Bidara Leaf Ethanol Extract on Lipid Profile Changes in Streptozotocin-Induced Type 2 Diabetes Mellitus Rats

Authors

  • Gusbakti Gusbakti Universitas Prima Indonesia
  • Michael Owen Simanullang Universitas Prima Indonesia
  • Edlin Edlin Universitas Prima Indonesia
  • Putri Handayani Universitas Prima Indonesia

DOI:

https://doi.org/10.46799/adv.v4i9.657

Keywords:

Type 2 Diabetes Mellitus, Dyslipidemia, Ethanol Extract of Bidara Leaves, Ziziphus Mauritiana, Lipid Profile

Abstract

This research concluded that the declining construction performance and schedule delays in the Kucing Liar Fan 7 project, reflected by an average Project Performance Factor of 0.82 and a cost overrun of approximately 10% beyond the available contingency, resulted from the interaction of multiple factors, including design readiness, change control, material planning, communication and coordination, supervisory competency, and constrained underground working conditions. These issues were not caused by a single factor, as Management, Method, Material, People, and Environment collectively accounted for 84.93% of the prioritized relative importance among the six investigated factors. The identified lessons were documented in a Lesson Learned Register and translated into a proposed Controlling Project Management Office (PMO) implementation framework through a four-phase roadmap consisting of organizational assessment and preparation, PMO development and pilot implementation, organizational integration, and continuous improvement. The proposed PMO was designed to strengthen governance, standardization, coordination, and knowledge management without replacing the existing balanced-matrix authority structure of Project Managers and functional departments.It is recommended that PT Freeport Indonesia’s Central Services Division prioritize design readiness and constructability reviews before construction authorization, strengthen project planning beyond analogous estimation through detailed work breakdown structures and integrated risk assessments, implement earned-value-based monitoring with standardized dashboards, and formally establish the proposed PMO to improve governance, communication, and knowledge management across future underground ventilation construction projects. Future research is recommended to evaluate PMO performance following organizational implementation, compare PMO maturity levels across other underground mining projects, and examine the integration of digital project management technologies, such as Building Information Modeling (BIM) and predictive analytics, into project governance.

References

Chen. (2018). Polyphenols, Insulin Sensitivity, and Lipid Metabolism in Diabetes. Nutrients.

Committee, A. D. A. P. P. (2025). Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2025. Diabetes Care, 48(Supplement 1), S27–S49. https://doi.org/10.2337/dc25-S002

Dhurat, R., & Sukesh, M. (2014). Principles and methods of preparation of platelet-rich plasma: A review and author’s perspective. Journal of Cutaneous and Aesthetic Surgery, 7(4), 189. https://doi.org/10.4103/0974-2077.150734

Djasang. (2017). Analisis Hasil Pemeriksaan Kadar Low-Density Lipoprotein (LDL-Chol). Jurnal Media Analis Kesehatan, 8(2), 43–51.

El Tahawy, N. F., Rifaai, R. A., Saber, E. A., Saied, S. R., & Ibrahim, R. A. (2017). Effect of Platelet Rich Plasma (PRP) Injection on the Endocrine Pancreas of the Experimentally Induced Diabetes in Male Albino Rats: A Histological and Immunohistochemical Study. Journal of Diabetes & Metabolism, 08(03). https://doi.org/10.4172/2155-6156.1000730

Furman, B. L. (2021). Streptozotocin-Induced Diabetic Models in Mice and Rats. Current Protocols.

Goyal, S. N. (2022). Experimental Models of Diabetes and Their Applications in Antidiabetic Drug Research. Diabetes Research and Clinical Practice.

Hasan, M. M. (2023). Bioactive Compounds and Antidiabetic Potential of Medicinal Plants. Journal of Herbal Medicine.

Hidayati, D., Setyorini, D., & Afrian Nuari, N. (2018). Differences Complications During Perinatal in History of Women With Diabetes Mellitus and Obesity Gestational. 9(2), 148–160.

Khan, M. A. (2019). Antidiabetic and antioxidant potential of Ziziphus mauritiana in rats. Journal of Ethnopharmacology, 238, 111–118. https://doi.org/10.1016/j.jep.2019.01.030

Kurniawaty, E., & Yanita, B. (2016). Faktor-Faktor yang Berhubungan dengan Kejadian Diabetes Melitus Tipe II. Majority, 5(2), 27–31.

Luo, J. (2021). Flavonoids and Their Protective Effects Against Oxidative Stress in Diabetes. Oxidative Medicine and Cellular Longevity.

Martin-Sole, O. (2016). Effects of platelet-rich plasma (PRP) on a model of renal ischemia-reperfusion in rats. PLoS ONE, 11(8), 1–16. https://doi.org/10.1371/journal.pone.0160703

Organization, W. H. (2016). Global Report on Diabetes. World Health Organization.

Perez, C. (2017). Pharmacological potential of Ziziphus jujuba: A comprehensive review on therapeutic perspectives. Journal of Ethnopharmacology, 207, 91–116. https://doi.org/10.1016/j.jep.2017.06.023

Plasma, I. (2018). Efek Infusa Umbi Garut (Marantha arundinaceae L) Terhadap Kadar Glukosa dan Insulin Plasma Tikus yang Diinduksi Streptozotocyn. Jurnal Mipa, 41(1), 34–39.

Rahmatullah, M., Ahmed, S., & Roy, P. (2020). Phytochemical and pharmacological potential of Ziziphus species: A review. Asian Journal of Research in Medical and Pharmaceutical Sciences, 8(2), 10–19.

Rais, R., Alimoradi, H., Hosseinzadeh, H., & Mohajeri, S. A. (2018). Beneficial Effect of Ficus carica Leaf Extract on Serum Lipids in Type II Diabetic Patients: A Double Blind, Randomized Controlled Trial. Saudi Journal of Biological Sciences, 25(2), 286–291. https://doi.org/10.1016/j.sjbs.2017.05.005

Ramalingam, S., Ramasamy, S. M., Vasu, G., & Gopalarishnan, R. (2020). Antihyperglycemic potential of back tea extract attenuates tricarboxylic acid cycle enzymes by modulating carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats. Indian Journal of Clinical Biochemistry, 35(3), 322–330. https://doi.org/10.1007/s12291-019-00831-2

Salem, N., Helmi, N., & Assaf, N. (2018). Renoprotective Effect of Platelet-Rich Plasma on Cisplatin-Induced Nephrotoxicity in Rats. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2018/9658230

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Published

2026-09-23

How to Cite

Gusbakti, G., Owen Simanullang, M. ., Edlin, E., & Handayani, P. . (2026). Effectiveness Test of Bidara Leaf Ethanol Extract on Lipid Profile Changes in Streptozotocin-Induced Type 2 Diabetes Mellitus Rats. Advances In Social Humanities Research, 4(9), 1094–1104. https://doi.org/10.46799/adv.v4i9.657